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Antiviral pyrazolopiridinone compounds |
Zef Konst, Yipin Lu, Robert Joseph Moreau, Naomi Rajapaksa, Galen Paul Shearn-Nance +5 more |
2025-06-24 |
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| 12171739 |
N4-phenyl-quinazoline-4-amine derivatives and related compounds as ErbB type I receptor tyrosine kinase inhibitors for the treatment of hyperproliferative diseases |
Joseph P. Lyssikatos, Julie Marie Hicks, Fredrik P. Marmsater |
2024-12-24 |
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| 12071441 |
10-(di(phenyl)methyl)-4-hydroxy-8,9,9A,10-tetrahydro-7H-pyrrolo[1′,2′:4,5]pyrazino[1,2-b]pyridazine-3,5-dione derivatives and related compounds as inhibitors of the orthomyxovirus replication for treating influenza |
Maxime Dauphinais, Rama Jain, Dennis Christofer Koester, James R. MANNING, Vanessa M. Marx +4 more |
2024-08-27 |
$34,027,000 |
| 11964989 |
KRas G12D inhibitors |
Xiaolun Wang, Aaron Craig Burns, James Gail Christensen, John Michael Ketcham, John David Lawson +21 more |
2024-04-23 |
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| 11912715 |
Fused tricyclic pyridazinone compounds useful to treat orthomyxovirus infections |
Rama Jain, Dennis Christofer Koester, James R. MANNING, Vanessa M. Marx, Daniel Poon +4 more |
2024-02-27 |
$41,139,000 |
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Pyrazolo[3,4-b]pyridine compounds as inhibitors of TAM and MET kinases |
Ronald Jay Hinklin, Shelley Allen, Patrick Barbour, Adam Cook, Joshua Ryan Dahlke +3 more |
2023-10-10 |
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Antiviral pyrazolopyridinone compounds |
Zef Konst, Yipin Lu, Robert Joseph Moreau, Naomi Rajapaksa, Galen Paul Shearn-Nance +5 more |
2023-06-06 |
$71,694,000 |
| 11629149 |
10-(di(phenyl)methyl)-4-hydroxy-8,9,9A,10-tetrahydro-7H-pyrrolo[1′,2′:4,5]pyrazino[1,2-b]pyridazine-3,5-dione derivatives and related compounds as inhibitors of the orthomyxovirus replication for treating influenza |
Maxime Dauphinais, Rama Jain, Dennis Christofer Koester, James R. MANNING, Vanessa M. Marx +4 more |
2023-04-18 |
$36,314,000 |
| 11453683 |
KRas G12D inhibitors |
Xiaolun Wang, Aaron Craig Burns, James Gail Christensen, John Michael Ketcham, John David Lawson +21 more |
2022-09-27 |
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| 11453677 |
Tricyclic compounds useful to treat orthomyxovirus infections |
Rama Jain, Dennis Christofer Koester, James R. MANNING, James Sutton, Benjamin R. TAFT +1 more |
2022-09-27 |
$36,805,000 |
| 11306310 |
MicroRNA inhibitor |
Zuoren Yu, Zhongmin Liu |
2022-04-19 |
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| 11174273 |
Quinazoline analogs as receptor tyrosine kinase inhibitors |
Eli M. Wallace, George T. Topalov, Joseph P. Lyssikatos, Alexandre Joseph Buckmelter |
2021-11-16 |
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| 11104676 |
Pyrazolo[3,4-b]pyridine compounds as inhibitors of TAM and MET kinases |
Ronald Jay Hinklin, Shelley Allen, Patrick Barbour, Adam Cook, Joshua Ryan Dahlke +3 more |
2021-08-31 |
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Fused tricyclic pyridazinone compounds useful to treat orthomyxovirus infections |
Rama Jain, Dennis Christofer Koester, James R. MANNING, Vanessa M. Marx, Daniel Poon +4 more |
2021-08-24 |
$18,886,000 |
| 11091486 |
Process for the preparation of pyrazolo[1,5-a]pyrimidines and salts thereof |
Stacey Spencer, Yutong Jiang, Julia Haas, Charles Todd Eary |
2021-08-17 |
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| 11072610 |
Antiviral pyridopyrazinedione compounds |
Christopher Becker, Xiaolin Li, Peichao Lu, Naomi Rajapaksa, David C. Tully +1 more |
2021-07-27 |
$104,843,000 |
| 10858366 |
Tricyclic compounds useful to treat orthomyxovirus infections |
Rama Jain, Dennis Christofer Koester, James R. MANNING, James Sutton, Benjamin R. TAFT +1 more |
2020-12-08 |
$132,345,000 |
| 10780073 |
N4-phenyl-quinazoline-4-amine derivatives and related compounds as ErbB type I receptor tyrosine kinase inhibitors for the treatment of hyperproliferative diseases |
Joseph P. Lyssikatos, Julie Marie Hicks, Fredrik P. Marmsater |
2020-09-22 |
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| 10669269 |
Substituted N-(1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide compounds as type III receptor tyrosine kinase inhibitors |
Mark Laurence Boys, Robert Kirk DeLisle, Erik James Hicken, April L. Kennedy, David A. Mareska +7 more |
2020-06-02 |
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| 10647730 |
Macrocyclic compounds as TRK kinase inhibitors |
Steven W. Andrews, Kevin Ronald Condroski, Julia Haas, Yutong Jiang, Gabrielle R. Kolakowski +2 more |
2020-05-12 |
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Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions |
Michael M. Miller, Claudio Mapelli, Martin Patrick Allen, Michael S. Bowsher, Eric P. Gillis +12 more |
2020-01-21 |
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| 10450347 |
Immunomodulators |
Michael M. Miller, Martin Patrick Allen, Ling Li, Claudio Mapelli, Maude A. Poirier +4 more |
2019-10-22 |
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| 10358463 |
Immunomodulators |
Michael M. Miller, Martin Patrick Allen, Ling Li, Michael S. Bowsher, Eric P. Gillis +4 more |
2019-07-23 |
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| 10221194 |
Quinazoline analogs as receptor tyrosine kinase inhibitors |
Eli M. Wallace, Joseph P. Lyssikatos, George T. Topalov, Alexandre Joseph Buckmelter |
2019-03-05 |
$52,115,000 |
| 10160764 |
Fused tricyclic pyridazinone compounds useful to treat orthomyxovirus infections |
Rama Jain, Dennis Christofer Koester, James R. MANNING, Vanessa M. Marx, Daniel Poon +4 more |
2018-12-25 |
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