Patent Leaderboard
USPTO Patent Rankings Data through Dec 31, 2025
MC

Michael John Costanzo — 27 Patents

BPBeta Pharma: 11 patents #3 of 20Top 15%
OPOrtho-Mcneil Pharmaceutical: 6 patents #67 of 449Top 15%
Johnson & Johnson: 4 patents #2,234 of 7,810Top 30%
OPOrtho Pharmaceutical: 3 patents #47 of 234Top 25%
MAMcneil Ab: 2 patents #42 of 127Top 35%
Bonney Lake, WA: #4 of 150 inventorsTop 3%
Washington: #3,049 of 76,902 inventorsTop 4%
Overall (All Time): #142,059 of 4,157,543Top 4%
27 Patents All Time
Michael John Costanzo has been granted 27 US patents while listed as an inventor at Beta Pharma. The first was granted in 1993 and the most recent in August 2025. Michael John Costanzo ranks #142,059 of 4,157,543 US inventors in our database (top 3.4%). Patent records list Michael John Costanzo in Bonney Lake, WA, US.

Issued Patents All Time

Showing 1–25 of 27 patents

Patent #TitleCo-InventorsDateApprox Value ⓘ
12390464 Treatment of EGFR mutant-related cancers using a combination of EGFR and CDK4/6 inhibitors Michael N. Greco, Michael Alan Green, Don Zhang, Jirong Peng 2025-08-19
12258365 Organophosphorus-substituted compounds as c-MET inhibitors and therapeutic uses thereof Don Zhang, Jirong Peng, Michael N. Greco, Michael Alan Green 2025-03-25
12187707 Pharmaceutical formulations of N-(2-(2-(dimethylamino)ethoxy)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylaminde and salts thereof Michael N. Greco, Michael Alan Green, Jirong Peng, Victoria Lynn Wilde, Don Zhang 2025-01-07
11414401 Substituted 2-anilinopyrimidine derivatives as EGFR modulators Jirong Peng, Michael N. Greco, Michael Alan Green, Victoria Lynn Wilde, Don Zhang 2022-08-16
11352341 2H-indazole derivatives as CDK4 and CDK6 inhibitors and therapeutic uses thereof Michael N. Greco, Jirong Peng, Don Zhang 2022-06-07
11180478 Pharmaceutical formulations of N-(2-(2-(dimethylamino) ethoxy)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide and salts thereof Michael N. Greco, Michael Alan Green, Jirong Peng, Victoria Lynn Wilde, Don Zhang 2021-11-23
11052086 2-anilinopyrimidine derivatives as therapeutic agents for treatment of brain cancers Michael N. Greco, Michael Alan Green, Jirong Peng, Victoria Lynn Wilde, Don Zhang 2021-07-06
10844045 Pharmaceutical salts N-(2-(2-(dimethylamino)ethoxy)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide and crystalline forms thereof Michael N. Greco, Michael Alan Green, Jirong Peng, Victoria Lynn Wilde, Don Zhang 2020-11-24
10590111 Substituted 2-anilinopyrimidine derivatives as EGFR modulators Jirong Peng, Michael N. Greco, Michael Alan Green, Victoria Lynn Wilde, Don Zhang 2020-03-17
10239864 2-H-indazole derivatives as cyclin-dependent kinase (CDK) inhibitors and therapeutic uses thereof Michael N. Greco, Jirong Peng, Victoria Lynn Wilde, Don Zhang 2019-03-26
9878994 2-H-indazole derivatives as cyclin-dependent kinase (CDK) inhibitors and therapeutic uses thereof Michael N. Greco, Jirong Peng, Victoria Lynn Wilde, Don Zhang 2018-01-30
8536189 Spiropiperidines for use as tryptase inhibitors Stephen C. Yabut, Brett A. Tounge, Bruce E. Maryanoff, Han-Cheng Zhang 2013-09-17 $51,022,000
8158792 Spiropiperidines for use as tryptase inhibitors Stephen C. Yabut, Brett A. Tounge, Bruce E. Maryanoff, Han-Cheng Zhang 2012-04-17 $41,469,000
7825110 Substituted spiroheterocycles Min Xiang, Mona Patel, Philip Rybczynski, Joseph Gunnet, Keith Demarest +3 more 2010-11-02 $70,286,000
7825111 Substituted spiroheterocycles Min Xiang, Mona Patel, Philip Rybczynski, Joseph Gunnet, Keith Demarest +3 more 2010-11-02 $70,286,000
7718673 Isonipecotamides for the treatment of integrin-mediated disorders William J. Hoekstra, Bruce E. Maryanoff 2010-05-18
7132418 Peptidyl heterocyclic ketones useful as tryptase inhibitors Bruce E. Maryanoef, Stephen C. Yabut 2006-11-07 $4,252,000
7081460 Quinazoline and quinazoline-like compounds for the treatment of integrin-mediated disorders William J. Hoekstra, Edward C. Lawson 2006-07-25 $10,380,000
6495523 Tricyclic monosaccharide derivatives useful in treating acute ischemia-induced neurodegeneration Bruce E. Maryanoff, Richard P. Shank 2002-12-17
6469036 Peptidyl heterocyclic ketones useful as tryptase inhibitors Bruce E. Maryanoff, Stephen C. Yabut 2002-10-22
6323219 Methods for treating immunomediated inflammatory disorders 2001-11-27
6069254 Carboxamide derivatives of piperidine for the treatment of thrombosis disorders William J. Hoekstra, Bruce E. Maryanoff 2000-05-30 $184,414,000
5827860 Peptidyl heterocycles useful in the treatment of thrombin related disorders Bruce E. Maryanoff 1998-10-27 $68,827,000
5827866 Peptidyl heterocycles useful in the treatment of thrombin related disorders Bruce E. Maryanoff 1998-10-27 $68,827,000
5523308 Peptidyl heterocycles useful in the treatment of thrombin related disorders Bruce E. Maryanoff 1996-06-04