| 12453776 |
Lipids and compositions for the delivery of therapeutics |
Muthiah Manoharan, Kallanthottathil G. Rajeev, Laxman Eltepu, Steven M. Ansell, Jianqi Chen |
2025-10-28 |
|
| 12435337 |
Inhibitors of expression and/or function |
Alan Whitmore, Julie BORGEL, Amy MCCARTHY, Graham CRAGGS, James LONGDEN +6 more |
2025-10-07 |
|
| 12397013 |
Extrahepatic delivery |
Jayaprakash K. Nair, Martin Maier, Vasant Jadhav, Stuart Milstein, Kirk Brown +8 more |
2025-08-26 |
|
| 12364762 |
Biodegradable lipids for the delivery of active agents |
Martin Maier, Akin Akinc, Shigeo Matsuda, Pachamuthu Kandasamy, Kallanthottathil G. Rajeev +3 more |
2025-07-22 |
|
| 12350338 |
Biodegradable lipids for the delivery of active agents |
Martin Maier, Akin Akinc, Shigeo Matsuda, Pachamuthu Kandasamy, Kallanthottathil G. Rajeev +3 more |
2025-07-08 |
|
| 12343398 |
Biodegradable lipids for the delivery of active agents |
Martin Maier, Akin Akinc, Shigeo Matsuda, Pachamuthu Kandasamy, Kallanthottathil G. Rajeev +3 more |
2025-07-01 |
|
| 12338438 |
Conjugated oligonucleotide compounds, methods of making and uses thereof |
Ahmad Ali MORTAZAVI, Viviana MANNELLA |
2025-06-24 |
|
| 12264328 |
Gene editing components, systems, and methods of use |
Giedrius Gasiunas, Alim Ladha, Vladimir Presnyak, Elisabeth Narayanan |
2025-04-01 |
|
| 12239709 |
Biodegradable lipids for the delivery of active agents |
Martin Maier, Akin Akinc, Shigeo Matsuda, Pachamuthu Kandasamy, Kallanthottathil G. Rajeev +3 more |
2025-03-04 |
|
| 12215068 |
Constrained lipids and methods of use thereof |
Stephen Scully, Ganapathy Subramanian Sankaran |
2025-02-04 |
|
| 12173288 |
Oligonucleotide-ligand conjugates and process for their preparation |
Muthiah Manoharan, Jayaprakash K. Nair, Pachamuthu Kandasamy, Shigeo Matsuda, Alexander V. Kelin +1 more |
2024-12-24 |
$122,375,000 |
| 12054739 |
Engineered retrons and methods of use |
Alim Ladha, Vladimir Presnyak, Inna Shcherbakova, Brian Goodman, Mario Rodriguez Mestre +2 more |
2024-08-06 |
|
| 12042541 |
Lipids and compositions for the delivery of therapeutics |
Muthiah Manoharan, Kallanthottathil G. Rajeev, Laxman Eltepu, Steven M. Ansell, Jianxin Chen |
2024-07-23 |
$3,785,000 |
| 12023383 |
Lipid compositions |
Muthiah Manoharan, Kallanthottathil G. Rajeev, David Butler, Michael E. Jung |
2024-07-02 |
$5,689,000 |
| 12005074 |
Extrahepatic delivery |
Jayaprakash K. Nair, Martin Maier, Vasant Jadhav, Stuart Milstein, Kirk Brown +8 more |
2024-06-11 |
$157,482,000 |
| 11866728 |
Engineered retrons and methods of use |
Alim Ladha, Vladimir Presnyak, Inna Shcherbakova, Brian Goodman, Mario Rodriguez Mestre +2 more |
2024-01-09 |
|
| 11773061 |
Cyclic lipids and methods of use thereof |
Stephen Scully |
2023-10-03 |
|
| 11725207 |
Serpina1 iRNA compositions and methods of use thereof |
Mark K. Schlegel, Maja Janas, Vasant Jadhav, Donald C. Foster, Muthiah Manoharan +10 more |
2023-08-15 |
$94,046,000 |
| 11712476 |
Lipids and compositions for the delivery of therapeutics |
Muthiah Mancharan, Kallanthottathil G. Rajeev, Laxman Eltepu, Steven M. Ansell, Jianxin Chen |
2023-08-01 |
$3,687,000 |
| 11679158 |
Biodegradable lipids for the delivery of active agents |
Martin Maier, Akin Akinc, Shigeo Matsuda, Pachamuthu Kandasamy, Kallanthottathil G. Rajeev +1 more |
2023-06-20 |
$348,027,000 |
| 11633480 |
Biodegradable lipids for the delivery of active agents |
Martin Maier, Akin Akinc, Shigeo Matsuda, Pachamuthu Kandasamy, Kallanthottathil G. Rajeev +1 more |
2023-04-25 |
$177,671,000 |
| 11633479 |
Biodegradable lipids for the delivery of active agents |
Martin Maier, Akin Akinc, Shigeo Matsuda, Pachamuthu Kandasamy, Kallanthottathil G. Rajeev +1 more |
2023-04-25 |
$177,671,000 |
| 11612657 |
Biodegradable lipids for the delivery of active agents |
Martin Maier, Akin Akinc, Shigeo Matsuda, Pachamuthu Kandasamy, Kallanthottathil G. Rajeev +1 more |
2023-03-28 |
$173,332,000 |
| 11590229 |
Biodegradable lipids for the delivery of active agents |
Martin Maier, Akin Akinc, Shigeo Matsuda, Pachamuthu Kandasamy, Kallanthottathil G. Rajeev +1 more |
2023-02-28 |
$352,136,000 |
| 11504391 |
Modified RNA agents with reduced off-target effect |
Mark K. Schlegel, Maja Janas, Vasant Jadhav, Donald C. Foster, Muthiah Manoharan +10 more |
2022-11-22 |
$391,864,000 |