Patent Leaderboard
USPTO Patent Rankings Data through Dec 31, 2025
WM

William Markland — 28 Patents

DYDyax: 20 patents #4 of 129Top 4%
VIVertex Pharmaceuticals Incorporated: 4 patents #369 of 896Top 45%
PEProtein Engineering: 3 patents #5 of 6Top 85%
ATAtmel: 1 patents #459 of 762Top 65%
Milford, MA: #10 of 332 inventorsTop 4%
Massachusetts: #3,526 of 88,656 inventorsTop 4%
Overall (All Time): #134,628 of 4,157,543Top 4%
28 Patents All Time
William Markland has been granted 28 US patents while listed as an inventor at Dyax. The first was granted in 1993 and the most recent in May 2024. William Markland ranks #134,628 of 4,157,543 US inventors in our database (top 3.2%). Patent records list William Markland in Milford, MA, US.

Issued Patents All Time

Showing 1–25 of 28 patents

Patent #TitleCo-InventorsDateApprox Value ⓘ
11980633 Method for treating cancer using a combination of DNA-damaging agents and DNA-PK inhibitors Diane Boucher, Shawn Hillier, Wanjung Tsai, Brian Hare, David A. Newsome +1 more 2024-05-14 $617,872,000
11110108 Method for treating cancer using a combination of DNA-damaging agents and DNA-PK inhibitors Diane Boucher, Shawn Hillier, Wanjung Tsai, Brian Hare, David A. Newsome +1 more 2021-09-07 $188,614,000
8663629 Kallikrein-binding “kunitz domain” proteins and analogues thereof Robert Charles Ladner 2014-03-04 $9,337,000
8431359 Nucleic acids encoding polypeptide inhibitors of human plasmin derived from the Kunitz domains Robert Charles Ladner 2013-04-30 $3,992,000
8283321 Kallikrein-binding “Kunitz domain” proteins and analogues thereof Robert Charles Ladner 2012-10-09 $2,664,000
8002891 Crystallization of C-Jun N-Terminal Kinase 3 (JNK3) Xiaoling Xie, Yong Gu, Michael Su, Paul R. Caron, Edward J. Fox +1 more 2011-08-23 $26,545,000
7919462 Inhibitors of human plasmin derived from the Kunitz domains Robert Charles Ladner 2011-04-05 $1,516,000
7893007 Directed evolution of novel binding proteins Robert Charles Ladner, Sonia Guterman, Bruce Lindsay Roberts, Arthur C. Ley, Rachel Kent 2011-02-22 $1,600,000
7628983 Kallikrein-binding “Kunitz domain” proteins and analogues thereof Robert Charles Ladner 2009-12-08 $5,531,000
7413537 Directed evolution of disulfide-bonded micro-proteins Robert Charles Ladner, Sonia Guterman, Bruce Lindsay Roberts, Arthur C. Ley, Rachel Kent 2008-08-19 $3,973,000
7383135 Methods of designing inhibitors for JNK kinases Xiaoling Xie, Yong Gu, Michael Su, Paul R. Caron, Edward J. Fox +1 more 2008-06-03 $29,737,000
7256094 Method for changing threshold voltage of device in resist asher Chungdar Daniel Wang 2007-08-14 $3,878,000
7208293 Directed evolution of novel binding proteins Robert Charles Ladner, Sonia Guterman, Bruce Lindsay Roberts, Arthur C. Ley, Rachel Kent 2007-04-24 $4,346,000
7118879 Method of recovering a nucleic acid encoding a proteinaceous binding domain which binds a target material Robert Charles Ladner, Sonia Guterman, Bruce Lindsay Roberts, Arthur C. Ley, Rachel Kent 2006-10-10 $989,000
7078383 ITI-D1 Kunitz domain mutants as HNE inhibitors Arthur C. Ley, Sonia Guterman, Rachel Kent, Bruce Lindsay Roberts, Robert Charles Ladner 2006-07-18 $1,588,000
6979538 Directed evolution of novel binding proteins Robert Charles Ladner, Sonia Guterman, Bruce Lindsay Roberts, Arthur C. Ley, Rachel Kent 2005-12-27 $2,555,000
6953674 Inhibitors of human plasmin derived from the kunitz domains Robert Charles Ladner 2005-10-11 $2,555,000
6423498 Variegated Kunitz domain peptide library and uses thereof Robert Charles Ladner 2002-07-23 $1,000,000
6333402 "Kallikrein-binding ""Kunitz domain"" proteins and analogues thereof" Robert Charles Ladner 2001-12-25
6103499 Inhibitors of human plasmin derived from the Kunitz domains Robert Charles Ladner 2000-08-15
6071723 Inhibitors of human plasmin derived from the Kunitz domains Robert Charles Ladner 2000-06-06
6057287 "Kallikrein-binding ""Kunitz domain"" proteins and analogues thereof" Robert Charles Ladner 2000-05-02
6010880 Inhibitors of human plasmin derived from the kunitz domains Robert Charles Ladner 2000-01-04
5837500 Directed evolution of novel binding proteins Robert Charles Ladner, Sonia Kosow Gutterman, Bruce Lindsay Roberts, Arthur C. Ley, Rachel Kent 1998-11-17
5663143 Engineered human-derived kunitz domains that inhibit human neutrophil elastase Arthur C. Ley, Robert Charles Ladner, Sonia Guterman, Bruce Lindsay Roberts, Rachel Kent 1997-09-02